March 15, 2002BloodOpen Access

Discrepancy between antithrombin activity methods revealed in Antithrombin Stockholm: do factor Xa–based methods overestimate antithrombin activity in some patients?

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Population

Patients with Philadelphia chromosome-positive acute lymphoblastic leukemia undergoing allogeneic…

Authors

JUJohanna UngerstedtKarolinska Institutet SSSam SchulmanVascular Medicine NENils EgbergUppsala University

Discussion

Member takes

Implication

May support T-cell depletion after anti-CD66 conditioning to limit GvHD; leaves open optimal strategies in prospective trials.

Structured PICO

Population

Patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) undergoing allogeneic hematopoietic cell grafts

Intervention

Conditioning regimens including 188 Re-labeled anti-CD66 (a, b, c, e) mAb without T-cell depletion or with early T-cell add backs

Outcome

Severe intestinal acute graft-versus-host disease (GvHD) and treatment-related mortality (TRM)safety

Efficient T-cell depletion is strongly recommended for allogeneic hematopoietic cell grafts after radioimmunotherapy conditioning with anti-CD66 mAb to prevent severe intestinal GvHD.

Cite This Study

Ungerstedt et al. (2002) studied this question.

synapsesocial.com/papers/6a8ff0b133cf5c591c0d2c06 https://doi.org/10.1182/blood-2001-11-0047

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Discrepancy between antithrombin activity methods revealed in Antithrombin Stockholm: do factor Xa–based methods overestimate antithrombin activity in some patients?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Discrepancy between antithrombin activity methods revealed in Antithrombin Stockholm: do factor Xa–based methods overestimate antithrombin activity in some patients?

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider