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The article is devoted to the consideration of protective properties of alpha-lipoic acid using in cardiac patients, including those with concomitant type 2 diabetes mellitus, which constitute a group of high and very high cardiovascular risk. The modern pathogenetic mechanisms of vascular wall damage in endothelial dysfunction, oxidative stress in cardiac patients, including those with concomitant type 2 diabetes mellitus, are considered in details. Particular attention in the article was paid to the role of pathogenetic based therapy using alpha-lipoic acid, which has a wide spectrum of pleiotropic effects, which affects oxidative stress indicators, atherogenic dyslipidemia and endothelial dysfunction, inflammation, atherosclerosis. Systematically, based on data from evidence-based medicine, features of the effects of alpha-lipoic acid on metabolic processes in the body are highlighted, it’s role in the antioxidant defense system, as well as it’s cytoprotective properties described, which justifies the rationality of the use of alpha-lipoic acid in cardiac patients.
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Zhuravlyova et al. (2018) studied this question.
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