Why the study?
Does terbutaline improve hypokalaemic paralysis in a patient with long QT syndrome and familial periodic paralysis?
Does terbutaline improve hypokalaemic paralysis in a patient with long QT syndrome and familial periodic paralysis?
Terbutaline provided temporary symptomatic relief of hypokalaemic paralysis in a patient with a complex syndrome including long QT and ventricular ectopy, though the condition ultimately proved fatal.
Answers are grounded in this paper and cite their sources.
Terbutaline yielded transient relief but fatal recurrence in this case; single report leaves its role in hypokalaemic paralysis with long QT unresolved.
In this paper a follow-up is presented of a case report initially described by Andersen in 1971. The patient presented with a syndrome including elements of familial periodic paralysis with hypokalaemia, long QT syndrome, ventricular ectopy, myopathy with fibre-type disproportion and dysmorphic features resembling Treacher Collins' syndrome. The main symptom was hypokalaemic paralysis. The episodes were accompanied by a lowered intracellular potassium content and an increase in intracellular sodium. Treatment with terbutaline, a Na/K-ATPase-stimulating drug, resulted in attack-free periods of approximately 9 months, after which the attacks reoccurred. The patient suffered severe attacks whenever treatment with terbutaline was stopped. The patient experienced two attacks of respiratory arrest, the second being fatal.
No takes yet. Share an insight, caveat, or question.
M. S. Djurhuus (1998) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: