Safety and Efficacy of Cyclosporine in Psoriatic Arthritis

Objectives The purpose of this study was to review evidence for the efficacy and safety of cyclosporine therapy in patients with psoriatic arthritis. Methods We performed a systematic literature review of available evidence using the electronic database PubMed. Results The available evidence suggests that cyclosporine may be an effective third-line treatment for psoriatic arthritis. However, its well-established side effect profile limits long-term use. Conclusion Cyclosporine may be an effective treatment option for psoriatic arthritis, but large randomized, placebo-controlled clinical trials with adequate sample sizes are needed to assess its impact on symptomatic control, inhibition of radiological disease progression, prevention of disability, and improvement of quality of life.