Key result
Ginseng administration (500mg/kg) in male rats under immobility stress significantly altered serum phosphate levels compared to stress alone, with no significant effect on magnesium or ALP levels.
Why the study?
Does ginseng alter serum phosphorus, magnesium, and ALP levels in male rats subjected to immobility stress?
RCT (n=24)
Randomly selected and divided
Does ginseng alter serum phosphorus, magnesium, and ALP levels in male rats subjected to immobility stress?
Ginseng administration significantly affects serum phosphate levels in male rats subjected to immobility stress, without altering magnesium or ALP levels.
Should not change clinical practice for stress-related mineral balance; leaves open hypothesis of ginseng-phosphate effects for human translation.
The ginseng root has been used for over 2000 years, in the belief that it is a panacea and promotes longevity. Ginseng glycopeptides have pharmacological effects, e.g., immunomodulatory, anti-tumor, anti-ulcer and hypoglycemic activities. Blood is one of the most important biologic fluids of the body in which under physiological and pathologic conditions, its compounds are subject to changes and fluctuations. For this study, 24 adult male rats were randomly selected. Rats were divided into three groups of 8 rats. Treatment and Ginseng treatment groups were transferred daily into the Restrainer and were under Immobility stress for 2 hours per day during 15 days. For ginseng group ginseng 500mg/kg (Ginsin capsule) was given daily after immobility stress. After 15 days, blood sampling was taken on the 15th day from groups and analyzed. There was no significant difference between all groups on magnesium and ALP levels. There was significant difference between treatment and ginseng treatment groups on serum phosphate also there was significant difference between treatment and control groups on phosphate level.
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Masood Khakzadihe (2014) conducted an RCT in Immobility stress (n=24). Ginseng vs. Immobility stress alone and unstressed control was evaluated on Serum phosphate, magnesium, and ALP levels. Ginseng administration (500mg/kg) in male rats under immobility stress significantly altered serum phosphate levels compared to stress alone, with no significant effect on magnesium or ALP levels.
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