Calcineurin regulates NFAT-dependent iNOS expression and protection of cardiomyocytes: Co-operation with Src tyrosine kinase

View Full Paper

Ask AI

Bookmark

Population

Isolated neonatal rat ventricular myocyte cultures and hearts isolated from wild-type or calcineurin Abeta…

Comparison

Bacterial lipopolysaccharide exposure or… vs Wild-type mice or untreated control cells

Design

Preclinical

Authors

Discussion

Preclinical data implicate calcineurin-iNOS in ischemia protection; leaves open translation to human myocardial injury.

Population

Isolated neonatal rat ventricular myocyte cultures and hearts isolated from wild-type or calcineurin Abeta knockout mice

Intervention

Bacterial lipopolysaccharide (LPS) exposure or transfection with constitutively active calcineurin or Src

Comparator

Wild-type mice (for knockout comparison) or untreated control cells

Outcome

iNOS expression and cell injury in response to simulated ischemia-reperfusionsurrogate

Calcineurin plays a cardioprotective role mediated by NFAT-dependent induction of iNOS expression and co-operativity with Src tyrosine kinase.

Obasanjo-Blackshire et al. (2006) studied this question.

View Full Paper

Ask AI

Bookmark