Lymphocytotoxic Antisera of Limited Iso‐Specificity After Skin Grafting in Man

Summary. Five out of six unrelated persons, grafted three times with skin from a single donor, produced cytotoxic antibodies against donor lymphocytes. Two antisera appeared to be monospecific, and the three other antisera contained antibodies of limited specificity. The iso‐specificities of the antisera showed good correspondence to the incompatibility in the HL‐A locus detected between donor and recipient by the group specific lymphocytotoxic antisera used. It is concluded that some strong skin cell antigens can be detected by lymphocyte typing that are of importance in the production of cytotoxic iso‐antibodies; it may therefore be possible to select suitable skin graft donor‐recipient pairs for production of lymphocytotoxic antisera of limited and desired iso‐specificity.