An attempt was made to evaluate the correlation between the result of lymphocyte typing and both the rejection type and the clinical course of 36 renal homograft recipients. Of the 36 patients, 27 had survived over 1 year and the remaining 9 for 6–12 months. Most of the recipients who were well matched had good kidney function and minimal rejection episodes. About half of those who were mismatched had poor renal function and severe rejection crises, whereas the other half had a benign course. There were almost no patients with poor clinical outcome who had not been classified as being mismatched. On the basis of these results it appears that use of this matching test for selection of donors would prevent the selection of particularly unfavorable donors, but would tend to err in ruling against other donors who may provide a well functioning transplant.
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Lee et al. (1967) studied this question.