Key result
P1Pi inhibited the coronary constrictor action of BAY K 8644 and selectively inhibited the inotropic action of norepinephrine without depressing basal myocardial contractility in perfused rat hearts.
Population
Langendorff-perfused rat hearts
Comparison
Palmitoyl carnitine isopropyl ester (P1Pi) vs Absence of P1Pi or atenolol
Design
Preclinical
Authors
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Should not change practice; leaves open whether selective L-type channel inhibition offers therapeutic value in humans.
P1Pi acts as a novel vasodilator by inhibiting activated L-type calcium channels without affecting sodium-calcium exchange in a rat heart model.
Reeves et al. (1995) studied this question. Isopropyl ester of palmitoyl carnitine (P1Pi) vs. Absence of P1Pi / Atenolol was evaluated on Coronary constriction and positive inotropic responses. P1Pi inhibited the coronary constrictor action of BAY K 8644 and selectively inhibited the inotropic action of norepinephrine without depressing basal myocardial contractility in perfused rat hearts.
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