Key result
Among 194 children under 2 years old hospitalized for acute respiratory tract infections, 30 (15.5%) were positive for human adenovirus, with an unexpected predominance of HAdV-F41.
Why the study?
The study was conducted to evaluate human adenovirus types associated with respiratory infections in young hospitalized children.
Observational (n=194)
Answers are grounded in this paper and cite their sources.
HAdV-F41 was unexpectedly found to be the predominant adenovirus type in children under 2 hospitalized for acute respiratory infections in Tunisia.
Aim: To evaluate human adenovirus (HAdV) types associated with respiratory infections, nasopharyngeal aspirations (NPA) were collected from children under 2 years old that were hospitalized for acute respiratory tract infections (ARTI) during 2018–2019. Methods: PCR was used for viral screening and select samples were then sequenced by Sanger sequencing. Results: Among 194 samples, 30 were HAdV-positive and 14 were chosen for further sequencing. HAdV-F41, C2 and C5 circulated simultaneously with an unexpected predominance of HAdV-F41. HAdV infection occurred year-round, with a peak in winter and early spring. The age group most affected was those younger than 6 months. Conclusion: Continued surveillance of HAdV infections is necessary and the contribution of HAdV-F41 in ARTI should be studied.
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Bouazizi et al. (2023) conducted an observational in Acute respiratory tract infections (ARTI) (n=194). Human adenovirus (HAdV) infection was evaluated on HAdV positivity and type distribution. Among 194 children under 2 years old hospitalized for acute respiratory tract infections, 30 (15.5%) were positive for human adenovirus, with an unexpected predominance of HAdV-F41.
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