Why the study?
Does clopidogrel reduce the rate of thrombosis in a rat model for venous microvascular failure?
Does clopidogrel reduce the rate of thrombosis in a rat model for venous microvascular failure?
Clopidogrel significantly reduces the rate of venous thrombosis in a rat microvascular anastomosis model, suggesting potential utility in free tissue transfer.
Clopidogrel merits evaluation in human free flap trials; leaves open translation from this rat model.
OBJECTIVE: To evaluate the effect of clopidogrel on the rate of thrombosis in a rat model for venous microvascular failure. STUDY DESIGN AND SETTING: Forty rats were treated with clopidogrel or saline control via gastric gavage in a randomized, blinded fashion. After allowing for absorption and activation, each femoral vein was isolated and a venous "tuck" procedure was performed. The bleeding time and vessel patency were subsequently evaluated. RESULTS: The rate of vessel thrombosis was decreased in the clopidogrel-treated group compared to controls (7.9% vs 31.4%, P < 0.025). The bleeding time was longer in the clopidogrel-treated group compared to controls (250 +/- 100 seconds vs 173 +/- 59 seconds, P < 0.015). CONCLUSION: Clopidogrel decreased the rate of thrombosis in the rat model for venous microvascular failure. SIGNIFICANCE: The use of clopidogrel may reduce the rate of venous thrombosis after free tissue transfer and may be indicated in select patients.
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Moore et al. (2007) studied this question.
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