Why the study?
Does clopidogrel alone or combined with aspirin reduce thrombogenesis in baboon models of arterial thrombosis?
Population
Baboon models of arterial thrombosis
Comparison
Clopidogrel alone or combined with aspirin vs Aspirin 10 mg/kg/d alone, or single agents…
Design
Preclinical
Authors
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Should not change practice; leaves open translation of aspirin-clopidogrel synergy to human arterial thrombosis.
Does clopidogrel alone or combined with aspirin reduce thrombogenesis in baboon models of arterial thrombosis?
In a nonhuman primate model, clopidogrel reduces stent and graft thrombosis, an effect that is significantly enhanced by the addition of aspirin.
Harker et al. (1998) studied this question.
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