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January 1, 2004Platelets

The effect of clopidogrel, aspirin and both antiplatelet drugs on platelet function in patients with peripheral arterial disease

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Why the study?

Does combination therapy with clopidogrel and aspirin improve platelet inhibition compared to monotherapy in patients with peripheral arterial disease?

Population

20 patients with peripheral arterial disease (PAD)

Comparison

Clopidogrel, aspirin, and then combination… vs Comparisons between clopidogrel monotherapy…

Design

Cohort

Authors

IJI.A. JagroopThe Royal Free HospitalMMMiltiadis I. MatsagasUniversity of ThessalyGGGeorge GeroulakosVascular / Pulmonary Vascular

Discussion

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Implication

Should not yet change antiplatelet practice in PAD; leaves open whether enhanced inhibition improves outcomes in RCTs.

Structured PICO

Does combination therapy with clopidogrel and aspirin improve platelet inhibition compared to monotherapy in patients with peripheral arterial disease?

P
Population
20 patients with peripheral arterial disease (PAD)
I
Intervention
Clopidogrel (75 mg/day), aspirin (75 mg/day), and then combination therapy of both drugs
C
Comparator
Comparisons between clopidogrel monotherapy, aspirin monotherapy, and combination therapy
O
Outcome
Platelet function indices including ADP-induced aggregation and spontaneous platelet aggregation (SPA)surrogate

In patients with peripheral arterial disease, combination therapy with clopidogrel and aspirin provides more potent platelet inhibition than either drug alone.

Limitations

  • Small sample size
  • Requires evaluation in appropriately designed clinical trials

Cite This Study

Jagroop et al. (2004) studied this question.

synapsesocial.com/papers/6a8b9240de5ec4e001e3c745https://doi.org/10.1080/09537105310001645960

Topics

Dual antiplatelet therapy
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