Why the study?
Does adding clopidogrel to aspirin improve platelet inhibition and overcome aspirin resistance in male patients with coronary artery disease?
Population
20 male patients with coronary artery disease treated with aspirin selected from 76 screened patients, and…
Comparison
Clopidogrel added to aspirin therapy for one week. vs Baseline platelet function and healthy subjects…
Design
Cohort
Follow-up
one week
Authors
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May enhance platelet inhibition in aspirin-resistant CAD; hypothesis-generating for clopidogrel non-responsiveness and outcomes.
Does adding clopidogrel to aspirin improve platelet inhibition and overcome aspirin resistance in male patients with coronary artery disease?
Adding clopidogrel to aspirin provides greater platelet inhibition and can overcome aspirin resistance in CAD patients, though a subset of patients exhibit clopidogrel non-responsiveness.
Dropiński et al. (2007) studied this question.
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