Why the study?
Does a clopidogrel loading dose reduce Arachidonic Acid (AA) induced platelet activation in volunteers and patients on aspirin?
Population
70 participants, comprising 34 volunteers on no medication and 36 patients on maintenance therapy with…
Comparison
Clopidogrel 600 mg loading dose vs Baseline (immediately prior to administration)
Design
Cohort
Follow-up
6 hours
Authors
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Clopidogrel may potentiate aspirin's AA effects beyond ADP; leaves open outcome impact in aspirin-treated patients.
Does a clopidogrel loading dose reduce Arachidonic Acid (AA) induced platelet activation in volunteers and patients on aspirin?
Clopidogrel has independent and aspirin-synergistic effects on AA-induced platelet activation, suggesting potentiation of aspirin's antiplatelet activity that is not detected by standard ADP-based assays.
Hobson et al. (2009) studied this question.
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