Why the study?
Does a 300 mg loading dose of clopidogrel provide effective early platelet inhibition in aspirin-treated patients undergoing elective PCI?
Population
50 patients on ongoing aspirin therapy (100 mg/day) undergoing elective percutaneous coronary intervention
Comparison
Clopidogrel 300 mg administered 2.5 hours prior… vs Baseline platelet function
Design
Cohort
Follow-up
2.5 hours
Authors
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May limit reliability of 300 mg clopidogrel loading for early PCI inhibition; hypothesis-generating for optimized regimens or monitoring.
Does a 300 mg loading dose of clopidogrel provide effective early platelet inhibition in aspirin-treated patients undergoing elective PCI?
A 300 mg loading dose of clopidogrel given 2.5 hours before elective PCI results in highly variable and often inadequate early platelet inhibition.
Aino Lepäntalo (2004) studied this question.
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