April 1, 2002Journal of Cardiovascular Pharmacology
Effects of Combined Therapy With Clopidogrel and Acetylsalicylic Acid on Platelet Glycoprotein Expression and Aggregation
Key result
Combined clopidogrel and ASA increases platelet disaggregation versus clopidogrel alone in chronic CAD.
- n=60
Why the study?
Does combined therapy with clopidogrel and acetylsalicylic acid improve platelet aggregation and glycoprotein expression compared to monotherapy in patients with chronic coronary artery disease?
Population
60 patients with chronic coronary artery disease
Comparison
Clopidogrel, acetylsalicylic acid, or… vs Active comparators
Design
RCT, randomly assigned to 3 treatment groups
Follow-up
14 days
Authors
Discussion
Loading...
Member takes
Implication
Increases platelet disaggregation in chronic CAD; extends monotherapy RCT data but leaves clinical outcomes open.
Study Design
Type
RCT (n=60)
Randomization
randomly assigned
Structured PICO
Does combined therapy with clopidogrel and acetylsalicylic acid improve platelet aggregation and glycoprotein expression compared to monotherapy in patients with chronic coronary artery disease?
P
Population
60 patients with chronic coronary artery disease randomly assigned to ASA, clopidogrel, or their combination for 14 days.
I
Intervention
Clopidogrel, acetylsalicylic acid (ASA), or combination of clopidogrel and ASA for 14 days
C
Comparator
Active comparators (ASA alone, clopidogrel alone, or combination)
O
Outcome
Platelet aggregation and expression of platelet membrane glycoproteins (P-selectin and PAC-1)surrogate
Combined therapy with clopidogrel and ASA significantly increases platelet disaggregation compared to monotherapy, suggesting potential superiority in high-risk coronary artery disease patients.
Cite This Study
Dörr et al. (2002) conducted an RCT in chronic coronary artery disease (n=60). Combination of clopidogrel and acetylsalicylic acid (ASA) vs. ASA alone or clopidogrel alone was evaluated on Platelet aggregation and expression of platelet membrane glycoproteins. Combined therapy with clopidogrel and ASA significantly increased platelet disaggregation compared to clopidogrel alone in patients with chronic coronary artery disease.