Why the study?
Does aspirin and dipyridamole reduce platelet accumulation on prosthetic femoro-popliteal grafts in patients undergoing bypass surgery?
Population
47 patients awaiting femoro-popliteal bypass using Dacron, polytetrafluorethylene, or saphenous vein grafts
Comparison
Aspirin and dipyridamole (ASA/DPM) capsules vs Placebo capsules
Design
RCT, randomized, double blind
Follow-up
7 days postoperative
Authors
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Supports ASA/DPM to curb early thrombogenicity on prosthetic grafts; extends RCT evidence for antiplatelet benefit in femoro-popliteal bypass.
Does aspirin and dipyridamole reduce platelet accumulation on prosthetic femoro-popliteal grafts in patients undergoing bypass surgery?
Aspirin and dipyridamole significantly reduce platelet accumulation on prosthetic (Dacron and PTFE) femoro-popliteal grafts early after surgery, potentially reducing the risk of graft failure.
Goldman et al. (1983) studied this question.
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