Key result
In a 15-year-old boy with COVID-19 and recurrent pericardial tamponade, treatment with pericardiocentesis, high-dose ibuprofen, colchicine, and the interleukin-1 antagonist anakinra led to full clinical and laboratory recovery.
Why the study?
Pericarditis is rare in COVID-19 infection, with only a few cases reported in children.
Case Report (n=1)
Recurrent pericardial tamponade associated with COVID-19 in children is rare but can be successfully managed with pericardiocentesis and interleukin-1 antagonists like anakinra.
Answers are grounded in this paper and cite their sources.
Recurrent tamponade may complicate pediatric COVID-19 pericarditis; hypothesis-generating for monitoring duration and therapy in children.
Background: Pericarditis is rare in Coronavirus disease 2019 (Covid-19) infection and only a few cases were reported in children. Case presentation: We present the case of a 15-year-old boy with symptoms of high fever and worsening chest pain during COVID-19 infection. Chest computer tomography (CT) and echocardiography confirmed pericardial tamponade requiring urgent drainage. Despite antiviral drug treatment, after 18 days severe attack developed requiring repeated pericardiocentesis. High dose ibuprofen, colchicin and the interleukin-1 antagonist, anakinra were given. Clinical symptoms and laboratory parameters improved after seven days of treatment. Autoinflammatory diseases were also suspected in the background the severe pericarditis, but genetic analysis ruled out any mutations. Conclusion: Pericarditis associated with COVID-19 infection may present in the acute phase or later as MIS-C. Though pericardial tamponade related to ongoing Covid-19 infection is rare in children, even biological treatment with interleukin-1 antagonist may be needed to control the inflammation.
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Győri et al. (2022) conducted a case report in COVID-19 with recurrent pericardial tamponade (n=1). Pericardiocentesis, high-dose ibuprofen, colchicine, and anakinra was evaluated on Clinical and laboratory improvement. In a 15-year-old boy with COVID-19 and recurrent pericardial tamponade, treatment with pericardiocentesis, high-dose ibuprofen, colchicine, and the interleukin-1 antagonist anakinra led to full clinical and laboratory recovery.
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