In rat tail arteries, alpha 1-adrenoceptors are uniformly distributed while alpha 2-adrenoceptors are located nearer the intima, where they mediate both vasoconstriction and endothelium-dependent vasodilation.
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Highlights surface-dependent vasoconstrictor potency in animal arteries; leaves open translation to human vascular responses or therapy.
Rajanayagam et al. (1993) studied this question.
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