Why the study?
Does acute and chronic administration of practolol alter cardiovascular responses to electrical stimulation and noradrenaline in pithed rats?
Does acute and chronic administration of practolol alter cardiovascular responses to electrical stimulation and noradrenaline in pithed rats?
Chronic administration of practolol in pithed rats may reduce noradrenaline release at sympathetic nerve endings, altering cardiovascular pressor and heart rate responses.
Answers are grounded in this paper and cite their sources.
No clinical implications from this animal study; leaves open translation of practolol's sympathetic effects to human therapy.
Chronic administration of practolol to the pithed rat produced a reduction in the pressor responses to electrical stimulation of the spinal cord and potentiation of pressor responses to high doses of (—)-noradrenaline compared to control animals. Acute administration of practolol caused an increase in the pressor responses to both electrical stimulation and high doses of noradrenaline. Heart rate responses to both forms of stimulation were less than control values after both acute and chronic dosage with practolol. It is possible that practolol reduces the release of noradrenaline at the sympathetic nerve ending after chronic administration.
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MJ Lewis (1974) studied this question.
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