Asymmetric Self‐Replication of Chiral 1,2‐Amino Alcohols by Highly Enantioselective Autoinductive Reduction

The product triggers the enantioselectivity. This concept is exemplified by the reduction of α-amino ketones with lithium aluminum hydride shown in Equation (1). By first modifying the reducing agent with product alcohols as chiral ligands, yields of 65–93% and ee values of 69–90% ee are obtained.