Renal Papillary Necrosis Associated with Analgesic Abuse

Case Studies1 January 1964Renal Papillary Necrosis Associated with Analgesic AbuseHERBERT F. R. PLASS, M.D.HERBERT F. R. PLASS, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1953, publications from Switzerland began to describe renal lesions associated with heavy usage of proprietary analgesics. Scandinavian physicians have pursued the subject more recently and have commented upon a "huge increase in the consumption of phenacetin" (1-4). Overuse of remedies similar to our "APC" tablets seems to be responsible. Groups of patients suffering with chronic painful arthritis and chronic headache syndromes have been found heavily involved. Suggestion of true addiction arises from an interesting group of factory workers studied, who were taking such compounds to enable them to "keep up the pace" required in their establishment. The possible extent...References1. LARSENMØLLER KCE: A renal lesion caused by abuse of Phenacetin. Acta Med. Scand. 164: 53, 1959. CrossrefMedlineGoogle Scholar2. LINDENEGFISCHERPEDERSENNISSEN OSJNI: Necrosis of the renal papillae and prolonged abuse of phenacetin. Acta Med. Scand. 165: 321, 1959. CrossrefMedlineGoogle Scholar3. NORDENFELDTRINGERTZ ON: Phenacetin takers dead with renal failure. Acta Med. Scand. 170: 385, 1961. CrossrefMedlineGoogle Scholar4. CLAUSENPEDERSEN EJ: Necrosis of the renal papillae in rheumatoid arthritis. Acta Med. Scand. 170 631, 1961. CrossrefMedlineGoogle Scholar5. MOOLTENSMITH SEIB: Fatal nephritis in chronic phenacetin poisoning. Amer. J. Med. 28: 127, 1960. CrossrefMedlineGoogle Scholar6. JOSHIDAYAPARKASHSTAGGSPARKERJOFFA WAHMI: Renal papillary necrosis after prolonged use of acetophenetidin. GP 26: 118, 1962. MedlineGoogle Scholar7. RAPOPORTWHITERANKING ALWGN: Renal damage associated with chronic phenacetin overdosage. Ann. Intern. Med. 57: 970, 1962. LinkGoogle Scholar8. SCHREINER GE: Editorial: The nephrotoxicity of analgesic abuse. Ann. Intern. Med. 57: 1047, 1962. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Minneapolis, MinnesotaFrom the University of Minnesota Medical School, Minneapolis, Minnesota.Requests for reprints should be addressed to Herbert F. R. Plass, M. D., 1935 Medical Arts Building, Minneapolis 2, Minnesota. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPhenacetin nephritisNephropathie durch AnalgeticaANALGESIC NEPHROPATHY: CHANGES IN VARIOUS PARAMETERS OF RENAL FUNCTION FOLLOWING CESSATION OF ANALGESIC ABUSEAnalgesic NephropathyPRISCILLA KINCAID-SMITH, M.B., F.R.A.C.P., D.C.P.Renal Papillary Necrosis: a Critique of PathogenesisEnvironment and the Kidney 1 January 1964Volume 60, Issue 1Page: 111-114KeywordsAnalgesicsArthritisAtrial premature contractionExcretionHeadachesIngestionLesionsNecrosisUrea Issue Published: 1 January 1964 PDF downloadLoading ...