What question did this study set out to answer?

To characterize the cytomorphologic features of medullary carcinoma of the thyroid and assess the diagnostic accuracy of fine-needle aspiration biopsy.

June 1, 2000Diagnostic Cytopathology

Cytologic diagnosis of medullary carcinoma of the thyroid gland

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To characterize the cytomorphologic features of medullary carcinoma of the thyroid and assess the diagnostic accuracy of fine-needle aspiration biopsy.
Investigated fine-needle aspiration (FNA) biopsies from 91 histologically verified medullary carcinomas of the thyroid (MCT).
Analyzed cytologic features alongside 14 additional cases diagnosed cytologically as MCT to evaluate diagnostic pitfalls and the role of immunocytochemistry.
FNA identified neoplasms with surgical indications in 98.9% of cases.
Specific tumor typing of MCT was accurately achieved in 89% of cases via FNA.
Primary cytologic markers included dispersed polygonal or triangular cells, azurophilic cytoplasmic granules, eccentrically placed nuclei with coarse granular chromatin, and amyloid.

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Implication

Diagnostic study demonstrates high diagnostic accuracy of fine-needle aspiration in medullary thyroid carcinoma, highlighting the utility of immunocytochemistry in ambiguous cases.

Cite This Study

Papaparaskeva et al. (2000) studied this question.

synapsesocial.com/papers/6a9018ef33cf5c591c0d390d https://doi.org/10.1002/(sici)1097-0339(200006)22:6<351::aid-dc5>3.0.co;2-t

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Implication

Diagnostic study demonstrates high diagnostic accuracy of fine-needle aspiration in medullary thyroid carcinoma, highlighting the utility of immunocytochemistry in ambiguous cases.

Cytologic diagnosis of medullary carcinoma of the thyroid gland

Key Points

Discussion

Implication

Cite This Study

Cytologic diagnosis of medullary carcinoma of the thyroid gland

Key Points

Discussion

Implication

Cite This Study

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