Reconfigurable Plasmonic Diastereomers Assembled by DNA Origami

Herein, we report self-assembled reconfigurable plasmonic diastereomers based on DNA nanotechnology. Up to three plasmonic chiral centers were organized by dynamic DNA origami platforms. Meanwhile, each chiral center could be individually controlled to switch between left-handed and right-handed states. Thus, complex and reconfigurable chiral plasmonic diastereomers with eight plasmonic stereoisomers were achieved, driven by programmed DNA reactions. With these plasmonic diastereomers, we demonstrated the existence of strong cross-talk near-field coupling among chiral centers, and the coupling of chiral centers could substantially contribute to the overall CD signals. Our work provides an important bottom-up approach for building complex and dynamic chiral plasmonics and for probing the interactions of plasmonic chiral centers.