July 1, 1991Anesthesia & Analgesia

Effects of Isoflurane, Midazolam, and Etomidate on Cardiovascular Responses to Stimulation of Central Nervous System Pressor Sites in Chronically Instrumented Cats

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Why the study?

Does administration of isoflurane, etomidate, or midazolam attenuate cardiovascular responses to central nervous system pressor site stimulation in chronically instrumented cats?

Structured PICO

Does administration of isoflurane, etomidate, or midazolam attenuate cardiovascular responses to central nervous system pressor site stimulation in chronically instrumented cats?

Population

Male and female cats (n = 23) chronically instrumented with bipolar stimulating electrodes in the regions of the ventrolateral hypothalamus and mesencephalic reticular formation

Intervention

Isoflurane (1.5%, 2.5%, and 3.0%), etomidate (3.0-mg/kg bolus and 0.4-mg·kg−1·h−1 infusion), and midazolam (7.5-mg/kg bolus and 0.2-mg·kg−1·h−1 infusion) administered in separate experimental groups

Comparator

Control experiments consisting of stimulation sequences at 1×, 2×, and 4× threshold current levels to elicit pressor responses before drug administration

Outcome

Responses of systolic arterial pressure (SAP), heart rate, infrarenal aortic blood flow, and lower body vascular resistance to central nervous system pressor site stimulationsurrogate

Isoflurane, etomidate, and midazolam attenuate cardiovascular responses to central nervous system stimulation, suggesting disruption of central cardiovascular control centers contributes to hemodynamic instability caused by these anesthetics.

Discussion

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Implication

May explain anesthetic hemodynamic instability in cats; leaves open translation to human cardiovascular control.

Cite This Study

Poterack et al. (1991) studied this question.

synapsesocial.com/papers/6a901985ed78fcc1e60d2d77 https://doi.org/10.1213/00000539-199107000-00013

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Effects of Isoflurane, Midazolam, and Etomidate on Cardiovascular Responses to Stimulation of Central Nervous System Pressor Sites in Chronically Instrumented Cats

Structured PICO

Discussion

Implication

Cite This Study

Effects of Isoflurane, Midazolam, and Etomidate on Cardiovascular Responses to Stimulation of Central Nervous System Pressor Sites in Chronically Instrumented Cats

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider