Atomic force microscopy reveals that viral RNA from HRV 2 rhinovirus undergoes conformational changes upon release in acidic conditions modeling cell endosomes.
May inform endosomal uncoating models; leaves open relevance to human HRV pathogenesis.
The mechanism of the release of viral RNA from the capsid under the conditions that model this process in cell endosomes upon the virus infection is studied by atomic force microscopy using the human common cold virus (HRV 2 rhinovirus) as an example. Characteristic images of the RNA-protein complex resulted from the release of nucleic acid from virus at pH 4.8–6.0 are presented. It is revealed that, upon its release, RNA undergoes a number of conformational transformations in free form or in a complex with viral protein.
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Sushko et al. (2010) studied this question.
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