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February 27, 2004Journal of VirologyOpen Access

Cryoelectron Microscopy Analysis of the Structural Changes Associated with Human Rhinovirus Type 14 Uncoating

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Population

Human rhinovirus type 14 (HRV14) and HRV2

Design

Preclinical

Authors

EHE.A. HewatLeiden UniversityDBDieter BlaasMax Perutz Labs

Discussion

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Implication

Offers mechanistic insight into HRV uncoating; leaves open whether VP1 channel targeting informs antiviral strategies.

Structured PICO

P
Population
Human rhinovirus type 14 (HRV14) and HRV2
I
Intervention
Cryoelectron microscopy analysis of uncoating
O
Outcome
Conformational changes of the capsid and viral proteins during uncoatingsurrogate

Cryoelectron microscopy reveals that HRV14 uncoating involves a 4% capsid expansion and VP1 movement to open a channel for RNA genome exit.

Cite This Study

Hewat et al. (2004) studied this question.

synapsesocial.com/papers/6a87cd73f8efd6d7e4fb14c1https://doi.org/10.1128/jvi.78.6.2935-2942.2004
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Also Consider

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