Population
Human rhinovirus (HRV3 and HRV16) virions complexed with a two-domain fragment of ICAM-1
Comparison
Incubation at physiological temperature vs Incubation at 4 degrees C
Design
Preclinical
Authors
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May guide capsid-targeted antivirals; leaves open human relevance from animal models.
Cryo-EM structural analysis reveals that ICAM-1 receptor binding mediates rhinovirus uncoating by locking the viral capsid in an expanded open state for subsequent genome release.
Li et al. (2003) studied this question.
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