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May 4, 2021Proceedings of the National Academy of SciencesOpen Access

ICAM-1 induced rearrangements of capsid and genome prime rhinovirus 14 for activation and uncoating

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Why the study?

Binding of rhinoviruses to ICAM-1 promotes virus activation, but the molecular details of this process remain unknown.

Population

Rhinovirus 14 virions and its complex with ICAM-1

Comparison

Rhinovirus 14 complexed with ICAM-1 vs uncomplexed rhinovirus 14 virions

Design

Cryo-electron microscopy structural study

Authors

DHD. HrebikMax Planck Institute of BiochemistryTFTibor FüzikCentral European Institute of TechnologyMGMária GondováCentral European Institute of Technology

Discussion

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Overview

Reveals ICAM-1-driven rhinovirus activation mechanism; leaves open therapeutic translation for common cold prevention.

Structured PICO

P
Population
Rhinovirus 14 virions and its complex with the soluble ectodomain of intercellular adhesion molecule-1 (ICAM-1)
I
Intervention
Binding of ICAM-1 to rhinovirus 14
C
Comparator
Unbound rhinovirus 14
O
Outcome
High-resolution structures of rhinovirus 14 virion and its complex with ICAM-1 determined by cryo-electron microscopysurrogate

The high-resolution structure of rhinovirus 14 in complex with ICAM-1 explains the molecular mechanism by which receptor binding primes enteroviruses for genome release.

Cite This Study

Hrebik et al. (2021) studied this question.

synapsesocial.com/papers/6a70988a8031ec7bb1dc7347https://doi.org/10.1073/pnas.2024251118
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure determination of coxsackievirus B3 to 3.5 Å resolution1995 · 69 citations
  2. 2Specific cleavage of viral proteins as steps in the synthesis and maturation of enteroviruses.1968 · 153 citations
  3. 3Discrimination among Rhinovirus Serotypes for a Variant ICAM-1 Receptor Molecule2004 · 23 citations
  4. 4Interaction of Coxsackievirus A21 with Its Cellular Receptor, ICAM-12001 · 98 citations
  5. 5Human-murine chimeras of ICAM-1 identify amino acid residues critical for rhinovirus and antibody binding1991 · 67 citations