Pathway of rhinovirus disruption by soluble intercellular adhesion molecule 1 (ICAM-1): an intermediate in which ICAM-1 is bound and RNA is released
Population
Rhinovirus serotypes 3 and 14
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
May facilitate rhinovirus genome delivery via persistent ICAM-1 binding; hypothesis-generating for entry-targeted antivirals.
Structured PICO
P
Population
Rhinovirus serotypes 3 and 14
I
Intervention
Soluble intercellular adhesion molecule 1 (sICAM-1)
O
Outcome
Pathway of rhinovirus interaction and disruption (particle formation, RNA release)
The ability of rhinovirus to remain bound to its receptor (ICAM-1) during uncoating may facilitate viral genome transport into the cytoplasm.
Cite This Study
Casasnovas et al. (1994) studied this question.