November 1, 1991Journal of VirologyOpen Access

Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1

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Population

Human rhinoviruses and two soluble forms of ICAM-1 [tICAM(453) and tICAM(185)]

Design

Preclinical

Authors

JGJ M GreveHarvard University CFCarla ForteAmgen (United States)CMChristopher W. MarlorAchillion Pharmaceuticals (United States)

Discussion

Member takes

Implication

Hypothesis-generating for soluble ICAM-1 constructs in rhinovirus; leaves open human translation pending prospective studies.

Structured PICO

Population

Human rhinoviruses and two soluble forms of ICAM-1 [tICAM(453) and tICAM(185)]

Intervention

tICAM(453) and tICAM(185)

Outcome

Virus-receptor binding, virus infectivity, and virus integritysurrogate

Soluble forms of ICAM-1 neutralize human rhinoviruses through distinct mechanisms involving direct competition and interference with entry or uncoating steps.

Cite This Study

Greve et al. (1991) studied this question.

synapsesocial.com/papers/6a6f57e5660549caf2c3e697 https://doi.org/10.1128/jvi.65.11.6015-6023.1991

View Full Paper

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Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of receptor-mediated rhinovirus neutralization defined by two soluble forms of ICAM-1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider