June 1, 1993Journal of VirologyOpen Access

Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules

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Structured PICO

Population

Human rhinoviruses (HRVs) in vitro assays

Intervention

Chimeric immunoadhesin molecules containing extracellular domains of ICAM-1 and constant regions of immunoglobulins (IC1-2D/IgA, IC1-2D/IgM, IC1-2D/IgG, IC1-5D/IgA)

Comparator

Soluble forms of ICAM-1 containing five and two domains (sICAM-1 and ICI-2D)

Outcome

Prevention of HRV plaque formation, inhibition of binding to cells, and disruption of virus capsid conformationsurrogate

Chimeric ICAM-1/IgA immunoadhesins effectively neutralize and disrupt human rhinoviruses at nanomolar concentrations, suggesting potential as a therapeutic agent.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Chimeric ICAM-1 agents merit further HRV study; animal data leave open clinical translation and efficacy.

Cite This Study

Martin et al. (1993) studied this question.

synapsesocial.com/papers/6a7cf2106ffc6062d77bf6d9 https://doi.org/10.1128/jvi.67.6.3561-3568.1993

View Full Paper

Ask AI

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Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules

Structured PICO

Discussion

Implication

Cite This Study

Efficient neutralization and disruption of rhinovirus by chimeric ICAM-1/immunoglobulin molecules

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider