September 15, 1991Proceedings of the National Academy of SciencesOpen Access

Identification of monoclonal antibody epitopes and critical residues for rhinovirus binding in domain 1 of intercellular adhesion molecule 1.

View Full Paper

Ask AI

Bookmark

Population

Human and murine intercellular adhesion molecule 1 (ICAM-1) chimeric and mutagenesis models

Design

Preclinical

Authors

AMAlan McClellandUniversity College Hospital JDJ. S. DebearAlexion Pharma (Switzerland)SYSusan YostMiles College

Discussion

Member takes

Implication

May offer targets for rhinovirus entry inhibition; leaves open clinical translation from animal models.

Structured PICO

Population

Human and murine intercellular adhesion molecule 1 (ICAM-1) chimeric and mutagenesis models

Intervention

Mutagenesis of ICAM-1 (chimeric exchanges, homologue replacement mutagenesis)

Outcome

Rhinovirus attachment and cell adhesionsurrogate

The study identifies the specific regions in domain 1 of ICAM-1 critical for human rhinovirus binding, providing molecular targets for viral entry inhibition.

Cite This Study

McClelland et al. (1991) studied this question.

synapsesocial.com/papers/6a70988b8031ec7bb1dc7379 https://doi.org/10.1073/pnas.88.18.7993

View Full Paper

Ask AI

Bookmark

Identification of monoclonal antibody epitopes and critical residues for rhinovirus binding in domain 1 of intercellular adhesion molecule 1.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification of monoclonal antibody epitopes and critical residues for rhinovirus binding in domain 1 of intercellular adhesion molecule 1.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider