January 1, 1990Proteins Structure Function and Bioinformatics
Modelling of the human intercellular adhesion molecule‐1, the human rhinovirus major group receptor
Population
Computational model of the amino-terminal domain of the intercellular adhesion molecule-1, the receptor for…
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Model supports ICAM-1–HRV14 interaction mechanism; leaves open experimental validation before therapeutic targeting.
Structured PICO
P
Population
Computational model of the amino-terminal domain of the intercellular adhesion molecule-1 (ICAM-1), the receptor for most human rhinovirus serotypes
I
Intervention
Structural modeling based on sequence and presumed structural homology to immunoglobulin constant domains
O
Outcome
Fit of the model into the putative receptor attachment site (canyon) on the human rhinovirus-14 (HRV14) surfacesurrogate
The structural model of ICAM-1 provides a plausible mechanism for its interaction with the human rhinovirus-14 receptor attachment site.
Cite This Study
Giranda et al. (1990) studied this question.