Key result
Soluble ICAM-1 demonstrated broad-spectrum antiviral activity against human rhinoviruses, with clinical isolates showing a mean IC50 of 417 nM, comparable to the 427 nM mean IC50 of laboratory reference strains.
Why the study?
Does soluble ICAM-1 inhibit rhinovirus reference strains and field isolates in vitro?
Does soluble ICAM-1 inhibit rhinovirus reference strains and field isolates in vitro?
Soluble ICAM-1 exhibits broad-spectrum antiviral activity against both laboratory reference strains and clinical field isolates of rhinovirus in vitro.
Hypothesis-generating for soluble ICAM-1 antivirals; clinical efficacy and safety remain untested.
The antiviral potency of soluble intercellular adhesion molecule-1 (ICAM-1; the major receptor for human rhinoviruses) was determined for a subset of American Type Culture Collection reference serotypes and field isolates of rhinovirus. The results indicate that soluble ICAM-1 exhibits a broad spectrum of activity against rhinoviruses and that field isolates have a sensitivity indistinguishable from that of laboratory strains.
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Ohlin et al. (1994) studied Rhinovirus infection (n=86). Soluble intercellular adhesion molecule-1 (tICAM) vs. Untreated virus control was evaluated on 50% inhibitory concentration (IC50) of cytopathic effect. Soluble ICAM-1 demonstrated broad-spectrum antiviral activity against human rhinoviruses, with clinical isolates showing a mean IC50 of 417 nM, comparable to the 427 nM mean IC50 of laboratory reference strains.