Why the study?
How do plasma levels of a-hANP, renin activity, angiotensin II, and aldosterone change during cardiac surgery with cardiopulmonary bypass?
How do plasma levels of a-hANP, renin activity, angiotensin II, and aldosterone change during cardiac surgery with cardiopulmonary bypass?
Cardiac surgery with cardiopulmonary bypass induces a significant intraoperative increase in plasma a-hANP levels and activates the renin-angiotensin-aldosterone system.
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Intraoperative a-hANP rise during partial CPB warrants no practice change; leaves open its role in RAAS modulation during cardiac surgery.
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Aoyama et al. (1992) studied this question.
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