August 1, 1979Circulation

Beneficial effects of pulsatile perfusion in the hypertrophied ventricle during ventricular fibrillation.

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Why the study?

Does pulsatile perfusion prevent subendocardial ischemia in hypertrophied hearts during ventricular fibrillation compared to linear perfusion?

Population

10 dogs with left ventricular hypertrophy produced by previous supravalvular aortic banding

Comparison

Pulsatile perfusion using 'bubble tubing' during… vs Linear perfusion at mean aortic root pressures…

Design

Preclinical

Follow-up

30 minutes per condition

Authors

TBThomas J. BixlerJohns Hopkins University PMP. G. MageeRoyal London Hospital JFJohn T. FlahertySwarthmore College

Discussion

Member takes

Implication

Pulsatile perfusion may protect subendocardium at low pressures in this model; leaves open translation to hypertrophied human hearts during VF.

Structured PICO

Does pulsatile perfusion prevent subendocardial ischemia in hypertrophied hearts during ventricular fibrillation compared to linear perfusion?

Population

10 dogs with left ventricular hypertrophy produced by previous supravalvular aortic banding

Intervention

Pulsatile perfusion using 'bubble tubing' (pulse pressure ≥20 mm Hg) during total cardiopulmonary bypass at mean aortic root pressures of 80 and 50 mm Hg for 30 minutes each

Comparator

Linear perfusion at mean aortic root pressures of 80 and 50 mm Hg for 30 minutes each

Outcome

Subendocardial PCO2 and PO2 (PmCO2 and PmO2) and myocardial blood flowsurrogate

Pulsatile perfusion may prevent subendocardial ischemia in hypertrophied hearts during ventricular fibrillation at lower perfusion pressures.

Cite This Study

Bixler et al. (1979) studied this question.

synapsesocial.com/papers/6a901bdcf2438114dcc90ac7 https://doi.org/10.1161/01.cir.60.2.141

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Implication

Pulsatile perfusion may protect subendocardium at low pressures in this model; leaves open translation to hypertrophied human hearts during VF.

Beneficial effects of pulsatile perfusion in the hypertrophied ventricle during ventricular fibrillation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Beneficial effects of pulsatile perfusion in the hypertrophied ventricle during ventricular fibrillation.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider