Key result
Volatile anaesthetics (isoflurane and sevoflurane) did not significantly depress urine output compared to intravenous propofol during elective surgical procedures.
Why the study?
Isoflurane markedly reduces urine output, but whether this decrease is a specific effect of volatile anaesthetics remained unclear.
Does volatile anaesthesia reduce urine output compared to propofol in patients undergoing elective surgery?
Population
Patients undergoing open thyroid surgery (n = 29) or open hysterectomy (n = 25)
Comparison
Volatile anaesthetics (isoflurane or sevoflurane) vs intravenous anaesthesia (propofol)
Design
Analysis of data from two randomized clinical trials
Authors
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Volatile anaesthetics may be used without added renal caution in elective procedures; hypothesis-generating and requires validation in randomized trials.
RCT (n=54)
sealed envelope technique
Yes
Does volatile anaesthesia reduce urine output compared to propofol in patients undergoing elective surgery?
Absolute Event Rate: 218% vs 132%
p-value: p=0.50
Volatile anaesthetics such as isoflurane and sevoflurane do not depress urine output more strongly than intravenous propofol during elective surgery.
Robert G. Hahn (2024) conducted an RCT in Elective surgery (thyroid surgery or open hysterectomy) (n=54). Volatile anaesthetics (isoflurane or sevoflurane) vs. Propofol was evaluated on Urine output after 150 minutes of thyroid surgery (p=0.50). Volatile anaesthetics (isoflurane and sevoflurane) did not significantly depress urine output compared to intravenous propofol during elective surgical procedures.
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