Why the study?
Does intravenous bumetanide reduce plasma vasopressin concentrations in patients undergoing major surgical procedures under general anaesthesia?
Does intravenous bumetanide reduce plasma vasopressin concentrations in patients undergoing major surgical procedures under general anaesthesia?
Intravenous bumetanide administered before major surgery may attenuate the rise in plasma vasopressin concentrations.
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May attenuate AVP rise in surgery; hypothesis-generating, needs RCTs before practice change.
During a study in seven patients on the endocrine response to major surgical procedures under general anaesthesia an incidental finding was that the administration of intravenous bumetanide prior to surgical stimulation led to reduced concentrations of plasma vasopressin (AVP) when compared with a control group of patients.
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Kaufman et al. (1987) studied this question.
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