Why the study?
Does high-dose intravenous morphine alter plasma arginine vasopressin levels and their relation to arterial pressure changes during open heart surgery?
Population
13 patients undergoing open heart surgery
Comparison
High doses of intravenous morphine as part of… vs Anaesthetic without high-dose intravenous morphine
Design
Cohort
Follow-up
During cardiopulmonary bypass
Authors
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High-dose morphine was associated with attenuated AVP rises during bypass; hypothesis-generating for effects on perioperative hemodynamics in cardiac surgery.
Does high-dose intravenous morphine alter plasma arginine vasopressin levels and their relation to arterial pressure changes during open heart surgery?
High-dose intravenous morphine reduces the sensitivity of the neuroendocrine reflex control of plasma AVP levels in response to falls in arterial pressure during cardiac surgery.
Woods et al. (1989) studied this question.
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