Why the study?
Does prophylactic low-dose vasopressin reduce the incidence of vasodilatory shock in patients with low ejection fraction on ACE inhibitors undergoing CABG?
Population
50 patients undergoing coronary artery bypass grafting with an ejection fraction between 30-40% and…
Comparison
Vasopressin 0.03 IU/min infused intraoperatively… vs Normal saline infused intraoperatively and for 4…
Design
RCT, Randomly divided in two groups, Double-blind
Follow-up
24 hours
Authors
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Supports prophylactic vasopressin in low-EF ACEi patients undergoing CABG; extends perioperative vasopressor evidence to this high-risk subgroup.
Does prophylactic low-dose vasopressin reduce the incidence of vasodilatory shock in patients with low ejection fraction on ACE inhibitors undergoing CABG?
Prophylactic low-dose vasopressin infusion during and after CABG reduces the incidence of vasodilatory shock and catecholamine requirements in patients with low ejection fraction receiving preoperative ACE inhibitors.
Παπαδόπουλος et al. (2010) studied this question.
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