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May 1, 1990The International Journal of Artificial Organs

Pulsatile bypass reduced but did not abolish the stress response of vasoactive hormone release; distinct hormone release patterns were observed based on underlying cardiac disease (e.g., greater AVP in MVD, greater renin-angiotensin in AVD/CAD).

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Why the study?

Does pulsatile cardiopulmonary bypass alter vasoactive hormone release compared to non-pulsatile bypass in adult patients undergoing cardiac surgery?

Population

38 adult patients with mitral valve disease, aortic valve disease, and coronary artery disease undergoing…

Comparison

Pulsatile cardiopulmonary bypass vs Non-pulsatile cardiopulmonary bypass

Design

Cohort

Follow-up

early post-operative period

Authors

TKT. K. KaulRSR. SwaminathanRCR. R. Chatrath

Discussion

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Overview

Pulsatile bypass may attenuate but not abolish hormone release; leaves open disease-specific tailoring of perfusion pending randomized trials.

Structured PICO

Does pulsatile cardiopulmonary bypass alter vasoactive hormone release compared to non-pulsatile bypass in adult patients undergoing cardiac surgery?

P
Population
38 adult patients with mitral valve disease (MVD), aortic valve disease (AVD), and coronary artery disease (CAD) undergoing cardiopulmonary bypass (pulsatile n=15, non-pulsatile n=23).
I
Intervention
Pulsatile cardiopulmonary bypass
C
Comparator
Non-pulsatile cardiopulmonary bypass
O
Outcome
Pattern of vasoactive hormone release (Arginine vasopressin, renin, aldosterone, noradrenaline) in response to surgical stress and cardiopulmonary bypasssurrogate

Different cardiac diseases exhibit distinct vasoactive hormone release patterns during cardiopulmonary bypass, and pulsatile bypass can attenuate this stress response.

Cite This Study

Kaul et al. (1990) studied this question.

synapsesocial.com/papers/6a76ce00656dd99464ec2d6dhttps://doi.org/10.1177/039139889001300506
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Attenuation of the stress response to cardiopulmonary bypass by the addition of pulsatile flow.1981 · 77 citations
  2. 2The Renin‐Angiotensin‐Aldosterone System and Hematologic Changes During Pulsatile and Nonpulsatile Cardiopulmonary Bypass1993 · 21 citations
  3. 3Role of sympathoadrenal and renin-angiotensin system in hemodynamic state after coronary artery bypass grafting.1987 · 4 citations
  4. 4Infusion of low-dose vasopressin improves left ventricular function during separation from cardiopulmonary bypass: A double-blind randomized study2012 · 23 citations
  5. 5Perioperative infusion of low- dose of vasopressin for prevention and management of vasodilatory vasoplegic syndrome in patients undergoing coronary artery bypass grafting-A double-blind randomized study2010 · 95 citations