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October 1, 1981CirculationOpen Access

Attenuation of the stress response to cardiopulmonary bypass by the addition of pulsatile flow.

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Why the study?

Does pulsatile flow during cardiopulmonary bypass reduce the hormonal stress response in patients undergoing cardiopulmonary bypass?

Population

26 patients undergoing cardiopulmonary bypass

Comparison

Pulsatile flow during cardiopulmonary bypass vs Routine (nonpulsatile) cardiopulmonary bypass

Design

Cohort

Follow-up

Immediate postoperative period (recovery room)

Authors

DPDaniel M. PhilbinFLFrederick H. LevineKKK Kono

Discussion

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Member takes

Overview

Pulsatile flow may blunt hormonal stress in bypass; hypothesis-generating and should not yet change practice.

Structured PICO

Does pulsatile flow during cardiopulmonary bypass reduce the hormonal stress response in patients undergoing cardiopulmonary bypass?

P
Population
26 patients undergoing cardiopulmonary bypass
I
Intervention
Pulsatile flow during cardiopulmonary bypass (average pulse pressure of 30 mm Hg)
C
Comparator
Routine (nonpulsatile) cardiopulmonary bypass
O
Outcome
Hormonal stress response (plasma vasopressin, epinephrine, norepinephrine, and renin activity levels during and after bypass)surrogate

Pulsatile flow during cardiopulmonary bypass significantly attenuates the vasopressin and catecholamine stress response compared to routine nonpulsatile flow.

Cite This Study

Philbin et al. (1981) studied this question.

synapsesocial.com/papers/6a8fb4734a3389b78e830679https://doi.org/10.1161/01.cir.64.4.808
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Renin‐Angiotensin‐Aldosterone System and Hematologic Changes During Pulsatile and Nonpulsatile Cardiopulmonary Bypass1993 · 21 citations
  2. 2Vasoactive Pressure Hormones during and after Cardiopulmonary Bypass1990 · 20 citations
  3. 3Peripheral vascular resistance and angiotensin II levels during pulsatile and no-pulsatile cardiopulmonary bypass.1979 · 150 citations
  4. 4Pulsatile flow during cardiopulmonary bypass preserves postoperative microcirculatory perfusion irrespective of systemic hemodynamics2012 · 133 citations
  5. 5Clinical Comparison of Pulsatile and Nonpulsatile Perfusion During Cardiopulmonary Bypass1997 · 34 citations