Key result
Pulsatile perfusion during cardiopulmonary bypass significantly improved postoperative creatinine clearance (SMD 2.48, p=0.004) compared to non-pulsatile perfusion.
Why the study?
Does pulsatile perfusion improve post-operative renal function in patients undergoing cardiac surgery with cardiopulmonary bypass?
Population
10 prospective studies pooling 1,185 human patients undergoing cardiac surgery with cardiopulmonary bypass.
Comparison
Pulsatile perfusion during cardiopulmonary bypass vs Non-pulsatile perfusion during cardiopulmonary…
Design
Meta-analysis
Follow-up
post-operative (intensive care unit)
Authors
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Supports pulsatile perfusion for renal protection in CPB; confirms meta-analytic benefit on postoperative creatinine clearance.
Meta-Analysis (n=1,185)
Does pulsatile perfusion improve post-operative renal function in patients undergoing cardiac surgery with cardiopulmonary bypass?
Standardized Mean Difference: 2.48
p-value: p=0.004
Pulsatile perfusion during cardiopulmonary bypass may offer renal preservation benefits, as evidenced by improved creatinine clearance and lower serum lactate levels post-operatively.
Sievert et al. (2012) conducted a meta-analysis in cardiac surgery (n=1,185). Pulsatile perfusion vs. Non-pulsatile perfusion was evaluated on post-operative renal function (creatinine clearance) (SMD 2.48, p=0.004). Pulsatile perfusion during cardiopulmonary bypass significantly improved postoperative creatinine clearance (SMD 2.48, p=0.004) compared to non-pulsatile perfusion.
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