Key result
Pulsatile perfusion during cardiopulmonary bypass significantly improved post-operative creatinine clearance (SMD 2.48) and reduced serum lactate levels compared with non-pulsatile perfusion.
Why the study?
Does pulsatile perfusion improve post-operative renal function in patients undergoing cardiac surgery?
Population
1,185 human subjects undergoing cardiac surgery with cardiopulmonary bypass across 10 prospective studies
Comparison
Pulsatile perfusion during cardiopulmonary bypass vs Non-pulsatile perfusion during cardiopulmonary…
Design
Meta-analysis
Follow-up
post-operative (in the intensive care unit)
Authors
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Pulsatile perfusion may preserve renal function during CPB; extends meta-analytic support for adoption in cardiac surgery.
Meta-Analysis (n=1,185)
Does pulsatile perfusion improve post-operative renal function in patients undergoing cardiac surgery?
Standardized Mean Difference: 2.48 (95% CI 0.79–4.16)
p-value: p=0.004
Pulsatile perfusion during cardiopulmonary bypass may offer renal preservation benefits, as evidenced by improved creatinine clearance and lower serum lactate levels.
Sievert et al. (2012) conducted a meta-analysis in Cardiac surgery requiring cardiopulmonary bypass (n=1,185). Pulsatile perfusion vs. Non-pulsatile perfusion was evaluated on Post-operative creatinine clearance (SMD 2.48, 95% CI 0.79-4.16, p=0.004). Pulsatile perfusion during cardiopulmonary bypass significantly improved post-operative creatinine clearance (SMD 2.48) and reduced serum lactate levels compared with non-pulsatile perfusion.
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