Why the study?
Does total and regional depulsation using a pulse-shaping device affect mean aortic pressure and peripheral resistance in an intact organism model?
Population
Intact organism preclinical model
Design
Preclinical
Authors
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Depulsation-induced pressure rise in animals warrants cautious interpretation; leaves open relevance to human nonpulsatile support.
Does total and regional depulsation using a pulse-shaping device affect mean aortic pressure and peripheral resistance in an intact organism model?
In an intact organism model, depulsation using an in-vivo pulse-shaping device leads to a significant increase in mean aortic pressure and peripheral resistance, indicating active physiologic responses to nonpulsatile flow.
M Many (1967) studied this question.
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