Key result
High cellular expression of ANGPTL4 in tongue cancer patients was independently associated with a significantly lower 5-year overall survival rate compared to low expression (HR 2.72).
Why the study?
ANGPTL4 promotes cancer cell migration and its mRNA was increased in lung-metastasized tongue cancer cells, prompting investigation into its association with lung metastasis and patient outcomes.
Does high ANGPTL4 expression or plasma concentration predict lung metastasis and poor overall survival in patients with tongue cancer?
Population
48 patients with tongue cancer
Comparison
High vs low ANGPTL4 expression and plasma concentration
Design
Observational cohort study
Follow-up
5 years
Authors
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May stratify tongue cancer risk for intensified surveillance; hypothesis-generating and requires prospective validation before clinical use.
Cohort (n=48)
No
Does high ANGPTL4 expression or plasma concentration predict lung metastasis and poor overall survival in patients with tongue cancer?
Hazard Ratio: 2.72 (95% CI 1.14–6.51)
Absolute Event Rate: 27% vs 68%
p-value: p=0.024
High cellular expression and plasma concentration of ANGPTL4 are associated with lung metastasis and poor overall survival in patients with tongue cancer, suggesting its potential as a prognostic biomarker.
Tanaka et al. (2022) conducted a cohort in Tongue cancer (n=48). High ANGPTL4 expression vs. Low ANGPTL4 expression was evaluated on Overall survival (HR 2.72, 95% CI 1.14-6.51, p=0.024). High cellular expression of ANGPTL4 in tongue cancer patients was independently associated with a significantly lower 5-year overall survival rate compared to low expression (HR 2.72).
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