HIV-1 nucleocapsid protein induces "maturation" of dimeric retroviral RNA in vitro.

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Population

345-base synthetic fragment of Harvey sarcoma virus RNA

Design

Preclinical

Authors

Discussion

NC chaperones retroviral RNA maturation in vitro; leaves open translation to in vivo HIV mechanisms or therapies.

Population

345-base synthetic fragment of Harvey sarcoma virus RNA

Intervention

Recombinant or synthetic HIV-1 nucleocapsid (NC) protein

Outcome

Conversion of a less stable form of dimeric RNA to a more stable form (maturation of the dimer)

HIV-1 nucleocapsid protein acts as an RNA chaperone to induce maturation of dimeric retroviral RNA in vitro.

Feng et al. (1996) studied this question.

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