Chronic kidney disease in hypertensive patients was associated with a high prevalence of lipid disorders (68.8% with >2 abnormalities) and significantly higher systolic blood pressure.
Observational
Does the presence of chronic kidney disease worsen the lipid profile and ambulatory blood pressure characteristics in patients with primary arterial hypertension?
Hypertensive patients with chronic kidney disease exhibit a significantly worse cardiovascular risk profile, characterized by highly prevalent atherogenic dyslipidemia and unfavorable ambulatory blood pressure patterns, compared to those without CKD.
Accelerated atherosclerosis and cardiovascular diseases are frequent complications in hypertensive patients with chronic kidney disease (CKD), being mainly driven by cardiovascular risk factors as lipid disorders and an unfavorable blood pressure profile. The objectives of the study were to evaluate the lipid profile and to assess the characteristics of blood pressure (BP) in patients with primary arterial hypertension associating chronic kidney disease (CKD) in a primary care population in Timis County, Romania. Lipid disorders were highly prevalent in hypertensive patients with CKD, consisting in hyper LDL-cholesterolemia in 50.3%, hypertriglyceridemia in 52%, low HDL-cholesterol levels in 35.8%. More than 2 lipid abnormalities were present in 68.8% of CKD hypertensive. CKD hypertensive patients, compared with those without CKD, presented a BP profile with higher systolic and diastolic office BP. On ambulatory blood pressure monitoring they also registred higher systolic and diastolic BP, the systolic BP (SBP), both for 24 h SBP, day-time and night-time SBP being statistically significant higher than in hypertensive patients without CKD. The circadian 24 h BP profile demonstrated in the CKD hypertensive population an unfavourable nocturnal profile in 67%, consisting of a high prevalence of the non-dipping profile and of nocturnal riser pattern.
Baaj et al. (2020) conducted an observational in Arterial hypertension with chronic kidney disease. Chronic kidney disease vs. Hypertensive patients without chronic kidney disease was evaluated on Lipid profile and blood pressure characteristics. Chronic kidney disease in hypertensive patients was associated with a high prevalence of lipid disorders (68.8% with >2 abnormalities) and significantly higher systolic blood pressure.